Article details

Kaplan et al. Heart Rhythm 2004;1:3-11.

Clinical reports from this article

GeneExonMutationDNA ChangeProtein ChangeControlsPatient# Affected RelativesNotesMutation details
JUP12G680fsX690c.2040_2041delGTp.Trp680GlyfsX11 0/0 4, 3TFC+, with Naxos Disease Functional data: reduced connexin43 expression at intercellular junctions, smaller and fewer gap junctions interconnecting ventricular myocytes on electron microscopy. Failure of mutant plakoglobin to localize normally at intercellular junctions. Mutation details